In vitroEffect of Actinomycin D on Human Neutrophil Function
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Actinomycin D (AMD) at concentrations that inhibit cellular RNA synthesis by 85% or more causes an acute phase of lethal cell degeneration in HeLa cultures beginning as early as 3 hr after drug exposure, resulting in the nearly complete loss of viable cells by 12 hr. The loss of cells during this acute phase of lethality is closely dose dependent. Vero, WI38, or L cells are not susceptible to t...
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Suppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D.
For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1990
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1990.tb01012.x